National Institute of Biology (NIB) is coordinating 7. Framework programme project which has 3,3 million EUR budget.

  •  IN THE SWIRL OF CHANGE
    IN THE SWIRL OF CHANGE
    Symposium on the environmental and climate changes
    with their impact on our waters and biodiversity
    Ljubljana, October 14 – 15, 2021
  • NIB plans to build a Biotechnological       Hub of the NIB (BTH-NIB)
    NIB plans to build a Biotechnological Hub of the NIB (BTH-NIB)
    The National Institute of Biology and the Ministry of Education, Science and Sport are starting to finance and implement the project "Biotechnological Hub of the National Institute of Biology".
  •  NIB RESPONDS TO THE SO-FAR-UNPRECEDENTED CRISIS of the new CORONA VIRUS PANDEMIC BY MOBILIZING KNOWLEDGE
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Services and products

 
 
  •  
  • Agriculture Industry Services

    National Institute of Biology is authorized by the Ministry of Agriculture and the Environment to perform defined tasks of public service for the protection of plants.

 
  •  
  • Research equipment, Training and Related Services

    The big research equipment is used as support to our research and educational activities and serves technological development in co-operation with commercial enterprises. We offer hands on training, consulting and technical auditing, development of protocols and workflows, organization of workshops too.

 
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  • Pharmaceutical and Biotechnology Industry Services

    We offer bioanalytical laboratory support, toxicology studies, genetic toxicology testing of different samples, residual DNA detection, improvements of production lines through systems biology, and cotoxicology studies.

 
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  • Mutagenicity analysis under GLP

    On the NIB we have certified GLP laboratory for testing mutagenicity with bacterial reverse mutation assay, or the Ames test (OECD 471).

 

09 Dec
National Institute of Biology (NIB) is coordinating 7. Framework programme project which has 3,3 million EUR budget.

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{frontpage}{/frontpage} National Institute of Biology (NIB) is coordinating 7. Framework programme project which has 3,3 million EUR budget. Project CytoThreat (Fate and effects of cytostatic pharmaceuticals in the environment and the identification of biomarkers for and improved risk assessment on environmental exposure)


National Institute of Biology (NIB) is coordinating
7. Framework programme project which has 3,3 million EUR budget.

Project CytoThreat (Fate and effects of cytostatic pharmaceuticals in the environment and the identification of biomarkers for and improved risk assessment on environmental exposure)



In October 2010 European Commission and National Institute of Biology signed a research contract about implementation of Collaborative project CytoThreat. Project proposal was prepared in January 2010 by NIB and nine European partners within FP7 programme Environment (FP7-ENV-2010). After positive evaluation of project proposal and negotiation that concluded in autumn 2010, European Commission will co-financed project in the amount of 2.582.959 EUR. Project duration is four years; from 1.1.2011 till 31.12.2014. So far NIB participated in numerous FP projects, but it is the first time that is coordinating a FP project. Project coordinator is prof. dr. Metka Filipič. Project homepage will be prepared within the first months after the project commencement.



Abstract of the Project:
CytoThreat addresses the need to assess the risks of pharmaceuticals released in the environment, focusing on cytostatic drugs because they are highly hazardous compounds due to their genotoxic properties which   may cause unexpected long term effects. Their release in the environment may lead to systemic ecological effects and increased cancer incidence, reduced fertility and malformations in the offspring in humans. The   occurrence, distribution and fate of selected widely used cytostatics in different aquatic matrices, their acute and chronic toxicity and impact on the stability of the genetic material in a variety of aquatic organisms representing   different trophic levels is addressed to provide data sets necessary for scientifically based risk assessment.   Special emphasis is put on the combined effects of environmentally relevant mixtures. A combination of  state-of-the art analytical chemistry, in vivo and in vitro systems, and 'OMICS' technologies is applied. In vivo   studies with zebrafish models 131m at identifying linkages between the genomic profiles, exposure t.ond1tions   and adverse effects in vertebrates to identify molecular biomarkers 'or adverse effects of specific groups of  cytostatics to be used as diagnostic markers and for predicting synergistic effects of combined exposures.  Comparative in vitro genotoxicity and tral1scriptomic studies with zebrafish and human derived cells will   provide additional information for the extrapolation of toxicological data to humans. Comparisons with the   hazardous effects of other groups of pharmaceuticals will provide knowledge on the magnitude of the problem.  CytoThreat will generate new knowledge on environmental and health risks of cytostatics and provide objective   arguments for recommendations and regulations. Partners form 5 member states and 2 associated countries   with complementary expertise in analytical chemistry, aquatic and genetic toxicology, and genomics and bioinformatics are involved.     

 
Partners:
• National Institute of Biology - coordinator
• The Jozef Stefan Institute (JSI), Slovenia
• RR&Co d.o.o., Slovenia
• Medical University of Vienna (MUW),, Austria
• Szent István University (SZIE), Hungry,
• The Second University of Naples (SUN) Italy,
• Spanish Council for Scientific Research (CSIC), Spain
• The Institute for Medical Research and Occupational Health (IMI), Croatia
• Institute for Multidisciplinary Research (IMSI), Srbia